PEDVAX-R, hergestellt von der Firma Schmidt-Nagel, Genf ACT-HIB, hergstellet von Aventis Pasteur MSD
Haemophilus influenzae, formerly called Pfeiffer's bacillus or Bacillus influenzae, is a non-motile Gram-negative coccobacillus first described in 1892 by Dr. Richard Pfeiffer during an influenza pandemic. It is generally aerobic, but can grow as a facultative anaerobe. H. influenzae was mistakenly considered to be the cause of the common flu until 1933, when the viral etiology of the flu became apparent. Still, H. influenzae is responsible for a wide range of clinical diseases. Because of its small genome, H. influenzae became the first free-living organism with its entire genome sequenced. Its genome consists of 1,830,140 base pairs of DNA and contains 1740 genes. The sequencing project, completed and published in Science in 1995, was conducted at The Institute for Genomic Research under the direction of Dr. Robert Fleischmann.
Serotypes In 1930, 2 major categories of H. influenzae were defined: the unencapsulated strains and the encapsulated strains. The pathogenesis of H. influenzae infections is not completely understood, although the presence of the encapsulated type b (HiB) is known to be the major factor in virulence. Their capsule allows them to resist phagocytosis and complement-mediated lysis in the non-immune host. Unencapsulated strains are less invasive, but they are able to induce an inflammatory response that causes disease, such as epiglottitis. Vaccination with Hib conjugate vaccines is effective in preventing infection, and several vaccines are now available for routine use.
Diseases Most strains of H. influenzae are opportunistic pathogens - that is, they usually live in their host without causing disease, but cause problems only when other factors (such as a viral infection or reduced immune function) create an opportunity. There are six generally recognized types of H. influenzae: a, b, c, d, e, and f. Naturally-acquired disease caused by H. influenzae seems to occur in humans only. In infants and young children, H. influenzae type B (HIB) causes bacteremia, and acute bacterial meningitis. Occasionally, it causes cellulitis, osteomyelitis, epiglottitis, and joint infections. Due to routine use of the HIB conjugate vaccine in the U.S. since 1990, the incidence of invasive HIB disease has decreased to 1.3/100,000 children. However, HIB remains a major cause of lower respiratory tract infections in infants and children in developing countries where vaccine is not widely used. Unencapsulated H. influenzae (non-B type) causes ear (otitis media) and eye (conjunctivitis) infections and sinusitis in children, and is associated with pneumoni
Haemophylus influenzae B Vacc., Haemophilus influencae B Vacc., Bacillus influencae Vacc., ACT-HIB, Haem-i-b., HIB. REMEDIA Homeopathy.
available potencies in Globuli or Dilution: D12, D15, D30, D200 C6, C7, C9, C10, C12, C15, C30, C200, 1M, 10M, 50M
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